Capric acid (CA10) is a 10-carbon medium-chain fatty acid abundant in the medium-chain
triglyceride ketogenic diet (MCT KD). The purpose of this study was to characterize acute …

Phosphodiesterase (PDE) enzymes are widely distributed throughout the body, having
numerous effects and functions. The use of on demand PDE5 inhibitors (-Is) for the treatment …

Epilepsy is one of the furthermost common neurodegenerative diseases affecting above 50
million individuals worldwide. The pathogenesis of epileptic seizures is not satisfactorily …

Purpose Pentylenetetrazole and maximal electroshock rodent seizure models are commonly
used to detect antiepileptic efficacy in drug development. The aim of this research was to …

Background Epilepsy, one of the most common neurological disorders, affects over 70
million people worldwide. Rhynchophylline displays a wide variety of pharmacologic …

The zebrafish is extensively used as a model organism for studying several disorders of the
central nervous system (CNS), including epilepsy. Some antiseizure drugs (ASDs) have …

Several studies with larvae and adult zebrafish have shown that old and new antiseizure
drugs (ASDs) produce discrepant results in seizure tests, locomotor activity or anxiety …

Pre-eclampsia is an important hypertensive pregnancy disorder and a main cause of
maternal and fetal morbidity and mortality. Children born from mothers with pre-eclampsia …

Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the
treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic …

Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient
and a dietary supplement. The present study was undertaken to assess the effect of PTE on …