CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that
affects motor neurons and voluntary muscle control. ALS heterogeneity includes the age of …

Our understanding of cancer biology has increased substantially over the past 30 years.
Despite this, and an increasing pharmaceutical company expenditure on research and …

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and
is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade …

Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR interference
and programmable base editing have transformed the manipulation of eukaryotic genomes …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

In recent decades, research scientists, molecular biologists, and pharmacologists have
placed a strong emphasis on cutting-edge nanostructured materials technologies to …

Glioblastoma multiforme (GBM) is one of the deadliest human cancers. Despite increasing
knowledge of the genetic and epigenetic changes that underlie tumour initiation and growth …

YAP1 is a transcriptional coactivator and the principal effector of the Hippo signaling
pathway, which is causally implicated in human cancer. Several YAP1 gene fusions have …