Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Several convergent destructive mechanisms such as oxidative stress, alveolar cell
apoptosis, extracellular matrix proteolysis and chronic inflammation contribute to chronic …

Diabetic nephropathy (DN) is now considered the leading cause of end-stage renal disease.
In diabetes, the accumulation of reactive oxygen species (ROS) and iron overload are …

Renal tubular damage plays a key role in the pathogenesis of diabetic kidney disease
(DKD), and one of the main pathological process associated with DKD in diabetic mice is the …

The balance between mitochondrial fission and fusion is crucial for mitochondria to perform
its normal cellular functions. We hypothesized that cigarette smoke (CS) disrupts this …

Mitochondrial reactive oxygen species (ROS) play an important role in diabetes
complications, including diabetic nephropathy (DN). Plasma free fatty acids (FFAs) as well …

Hydrogen sulfide (H2S) therapy protects nondiabetic animals in various models of
myocardial injury, including acute myocardial infarction and heart failure. Here, we sought to …

Background Chronic obstructive pulmonary disease (COPD) has been emerging as a great
health problem in world. Cigarette smoke is known to cause oxidative stress and deplete …

Aims: Oxidants have been implicated in the pathophysiology of idiopathic pulmonary fibrosis
(IPF), especially in myofibroblastic differentiation. We aimed at testing the hypothesis that …

Electronic cigarettes represent an increasingly significant proportion of today's consumable
tobacco products. E‐cigarettes contain several chemicals which may promote oral diseases …