Genotype imputation for genome-wide association studies

J Marchini, B Howie - Nature Reviews Genetics, 2010 - nature.com
In the past few years genome-wide association (GWA) studies have uncovered a large
number of convincingly replicated associations for many complex human diseases …

A review of feature selection techniques in bioinformatics

Y Saeys, I Inza, P Larranaga - bioinformatics, 2007 - academic.oup.com
Feature selection techniques have become an apparent need in many bioinformatics
applications. In addition to the large pool of techniques that have already been developed in …

[HTML][HTML] Eight high-quality genomes reveal pan-genome architecture and ecotype differentiation of Brassica napus

JM Song, Z Guan, J Hu, C Guo, Z Yang, S Wang, D Liu… - Nature plants, 2020 - nature.com
Rapeseed (Brassica napus) is the second most important oilseed crop in the world but the
genetic diversity underlying its massive phenotypic variations remains largely unexplored …

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

Y Li, CJ Willer, J Ding, P Scheet… - Genetic …, 2010 - Wiley Online Library
Genome‐wide association studies (GWAS) can identify common alleles that contribute to
complex disease susceptibility. Despite the large number of SNPs assessed in each study …

Tight junction defects in patients with atopic dermatitis

A De Benedetto, NM Rafaels, LY McGirt… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

[HTML][HTML] Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering

SR Browning, BL Browning - The American Journal of Human Genetics, 2007 - cell.com
Whole-genome association studies present many new statistical and computational
challenges due to the large quantity of data obtained. One of these challenges is haplotype …

Linkage disequilibrium—understanding the evolutionary past and mapping the medical future

M Slatkin - Nature Reviews Genetics, 2008 - nature.com
Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …

STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement

J Little, JPT Higgins, JPA Ioannidis… - … Official Publication of …, 2009 - Wiley Online Library
Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …

Genome-wide association studies for common diseases and complex traits

JN Hirschhorn, MJ Daly - Nature reviews genetics, 2005 - nature.com
Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

A haplotype map of the human genome

… Consortium Altshuler David altshuler@ molbio. mgh … - Nature, 2005 - nature.com
Inherited genetic variation has a critical but as yet largely uncharacterized role in human
disease. Here we report a public database of common variation in the human genome: more …