Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …

The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …

Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's
disease and related neurodegenerative diseases. Lowering αSyn is being actively …

Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related
neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein …

Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …

Synucleinopathies are a group of neurodegenerative diseases with common pathological
lesions associated with the excessive accumulation and abnormal intracellular deposition of …

Human serum albumin (HSA), the most abundant protein in plasma and cerebrospinal fluid,
not only serves as a crucial carrier of various exogenous and endogenous ligands but also …

Parkinson's disease (PD) pathology is characterized by the loss of dopaminergic neurons of
the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites (LN) …

In recent years, due to the aging of the population and the development of diagnostic
medicine, the number of identified diseases associated with the accumulation of amyloid …

Parkinson's disease (PD) is a complex neurodegenerative disease characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and the widespread …