Inflammasomes in neuroinflammatory and neurodegenerative diseases
S Voet, S Srinivasan, M Lamkanfi… - EMBO molecular …, 2019 - embopress.org
Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …
Pharmacological inhibitors of the NLRP3 inflammasome
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …
which deal with a plethora of pathogenic products and cellular products associated with …
The NLRP3 inflammasome: contributions to inflammation-related diseases
Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …
innate immune responses by activating caspase-1 and the inflammatory cytokines …
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
BA McKenzie, MK Mamik, LB Saito… - Proceedings of the …, 2018 - National Acad Sciences
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS of
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …
NLRP3 inflammasome and its inhibitors: a review
BZ Shao, ZQ Xu, BZ Han, DF Su, C Liu - Frontiers in pharmacology, 2015 - frontiersin.org
Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …
NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes
A Gustin, M Kirchmeyer, E Koncina, P Felten… - PloS one, 2015 - journals.plos.org
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or
protein aggregates. The brain resident macrophages, microglia, are able to trigger an …
protein aggregates. The brain resident macrophages, microglia, are able to trigger an …
The role of the inflammasome in neurodegenerative diseases
F Piancone, F La Rosa, I Marventano, M Saresella… - Molecules, 2021 - mdpi.com
Neurodegenerative diseases are chronic, progressive disorders that occur in the central
nervous system (CNS). They are characterized by the loss of neuronal structure and function …
nervous system (CNS). They are characterized by the loss of neuronal structure and function …
Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: an update
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …
no specific or effective treatment. In the last two decades, much has been learned about the …
[HTML][HTML] Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis
X Zhang, Y Zhang, R Li, L Zhu, B Fu, T Yan - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder,
which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed …
which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed …
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
S Voet, C Mc Guire, N Hagemeyer, A Martens… - Nature …, 2018 - nature.com
Microglia, the mononuclear phagocytes of the central nervous system (CNS), are important
for the maintenance of CNS homeostasis, but also critically contribute to CNS pathology …
for the maintenance of CNS homeostasis, but also critically contribute to CNS pathology …