Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS of
unknown cause that remains incurable. Inflammasome-associated caspases mediate the …

Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …

Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or
protein aggregates. The brain resident macrophages, microglia, are able to trigger an …

Neurodegenerative diseases are chronic, progressive disorders that occur in the central
nervous system (CNS). They are characterized by the loss of neuronal structure and function …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder,
which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed …

Microglia, the mononuclear phagocytes of the central nervous system (CNS), are important
for the maintenance of CNS homeostasis, but also critically contribute to CNS pathology …