Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects
M van den Buuse - Schizophrenia bulletin, 2010 - academic.oup.com
In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …
[HTML][HTML] Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders
D Schubert, GJM Martens, SM Kolk - Molecular psychiatry, 2015 - nature.com
The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a
conglomerate of highly specialized brain areas and has been implicated to have a role in …
conglomerate of highly specialized brain areas and has been implicated to have a role in …
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
Schizophrenia is a severe mental illness that afflicts nearly 1% of the world's population.
One of the cardinal pathological features of schizophrenia is perturbation in synaptic …
One of the cardinal pathological features of schizophrenia is perturbation in synaptic …
[HTML][HTML] Schizophrenia and depression co-morbidity: what we have learned from animal models
JN Samsom, AHC Wong - Frontiers in psychiatry, 2015 - frontiersin.org
Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …
Animal models of gene–environment interaction in schizophrenia: A dimensional perspective
Y Ayhan, R McFarland, MV Pletnikov - Progress in neurobiology, 2016 - Elsevier
Schizophrenia has long been considered as a disorder with multifactorial origins. Recent
discoveries have advanced our understanding of the genetic architecture of the disease …
discoveries have advanced our understanding of the genetic architecture of the disease …
[HTML][HTML] Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes
CM O'tuathaigh, M Hryniewiecka, A Behan… - …, 2010 - nature.com
Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use
conferring even greater risk. A high–low activity catechol-O-methyltransferase (COMT) …
conferring even greater risk. A high–low activity catechol-O-methyltransferase (COMT) …
Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene× …
L Desbonnet, C O'Tuathaigh, G Clarke… - Brain, behavior, and …, 2012 - Elsevier
There is a paucity of animal models by which the contributions of environmental and genetic
factors to the pathobiology of psychosis can be investigated. This study examined the …
factors to the pathobiology of psychosis can be investigated. This study examined the …
Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation
IH Deakin, W Nissen, AJ Law, T Lane, R Kanso… - Cerebral …, 2012 - academic.oup.com
Abstract Neuregulin 1 (NRG1) is a growth factor involved in neurodevelopment and
plasticity. It is a schizophrenia candidate gene, and hippocampal expression of the NRG1 …
plasticity. It is a schizophrenia candidate gene, and hippocampal expression of the NRG1 …
[HTML][HTML] Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia
N Takashima, YS Odaka, K Sakoori, T Akagi… - PLoS …, 2011 - journals.plos.org
Recent genetic linkage analysis has shown that LRRTM1 (Leucine rich repeat
transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized …
transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized …
Schizophrenia‐related endophenotypes in heterozygous neuregulin‐1 'knockout'mice
CMP O'Tuathaigh, M Harte, C O'Leary… - European journal of …, 2010 - Wiley Online Library
Abstract Neuregulin‐1 (NRG1) has been shown to play a role in glutamatergic
neurotransmission and is a risk gene for schizophrenia, in which there is evidence for …
neurotransmission and is a risk gene for schizophrenia, in which there is evidence for …