High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …

Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure
oxygen in an augmented atmospheric pressure. Although it has been used for years, the …

Various strategies can be employed to prevent and manage altitude illnesses, including
habituation, oxygenation, nutritional support, and medication. Nevertheless, the utilization of …

Immune outcomes are key mediators of many health benefits of exercise and are
determined by exercise type, dose (frequency/duration, intensity), and individual …

Mitochondria are complex endosymbionts that evolved from primordial purple nonsulfur
bacteria. The incorporation of bacteria-derived mitochondria facilitates a more efficient and …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …