Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials
H Lu, Q Zhou, J He, Z Jiang, C Peng, R Tong… - Signal transduction and …, 2020 - nature.com
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …
that aberrant PPIs are associated with various diseases, including cancer, infectious …
Chasing molecular glue degraders: screening approaches
A Domostegui, L Nieto-Barrado… - Chemical Society …, 2022 - pubs.rsc.org
Protein–protein interactions (PPIs) govern all biological processes. Some small molecules
modulate PPIs through induced protein proximity. In particular, molecular glue degraders …
modulate PPIs through induced protein proximity. In particular, molecular glue degraders …
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions
3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …
Plasma membrane H+-ATPase regulation in the center of plant physiology
J Falhof, JT Pedersen, AT Fuglsang, M Palmgren - Molecular plant, 2016 - cell.com
The plasma membrane (PM) H+-ATPase is an important ion pump in the plant cell
membrane. By extruding protons from the cell and generating a membrane potential, this …
membrane. By extruding protons from the cell and generating a membrane potential, this …
Low ABA concentration promotes root growth and hydrotropism through relief of ABA INSENSITIVE 1-mediated inhibition of plasma membrane H+-ATPase 2
R Miao, W Yuan, Y Wang, I Garcia-Maquilon… - Science …, 2021 - science.org
The hab1-1abi1-2abi2-2pp2ca-1 quadruple mutant (Qabi2-2) seedlings lacking key
negative regulators of ABA signaling, namely, clade A protein phosphatases type 2C …
negative regulators of ABA signaling, namely, clade A protein phosphatases type 2C …
Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta… - Journal of medicinal …, 2017 - ACS Publications
Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …
Modulators of protein–protein interactions
LG Milroy, TN Grossmann, S Hennig… - Chemical …, 2014 - ACS Publications
Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …
14-3-3 proteins act as intracellular receptors for rice Hd3a florigen
Abstract 'Florigen'was proposed 75 years ago to be synthesized in the leaf and transported
to the shoot apex, where it induces flowering. Only recently have genetic and biochemical …
to the shoot apex, where it induces flowering. Only recently have genetic and biochemical …
Structural insights into the functional roles of 14-3-3 proteins
V Obsilova, T Obsil - Frontiers in molecular biosciences, 2022 - frontiersin.org
Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …
extracellular environment to intracellular compartments, thereby eliciting an appropriate …
Structure and activation mechanism of the hexameric plasma membrane H+-ATPase
The S. cerevisiae plasma membrane H+-ATPase, Pma1, is a P3A-type ATPase and the
primary protein component of the membrane compartment of Pma1 (MCP). Like other …
primary protein component of the membrane compartment of Pma1 (MCP). Like other …