Lung organoids: current uses and future promise

CE Barkauskas, MI Chung, B Fioret, X Gao… - …, 2017 - journals.biologists.com
Lungs are composed of a system of highly branched tubes that bring air into the alveoli,
where gas exchange takes place. The proximal and distal regions of the lung contain …

CellRank for directed single-cell fate mapping

M Lange, V Bergen, M Klein, M Setty, B Reuter… - Nature …, 2022 - nature.com
Computational trajectory inference enables the reconstruction of cell state dynamics from
single-cell RNA sequencing experiments. However, trajectory inference requires that the …

Nasal mucus proteome and its involvement in allergic rhinitis

PV Tomazic, B Darnhofer… - Expert review of …, 2020 - Taylor & Francis
Introduction: Nasal mucus is the first line defense barrier against various pathogens
including allergens. Proteins in nasal mucus maybe used as biomarkers for diagnosis or …

LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation

Q Liao, Z Zeng, X Guo, X Li, F Wei, W Zhang, P Chen… - Oncogene, 2014 - nature.com
Abstract Tumor-associated macrophage (TAM)-related chronic inflammation and interleukin-
6 (IL-6) contribute to the progression of nasopharyngeal carcinoma (NPC). In this study, we …

Molecular evolution of the bactericidal/permeability-increasing protein (BPIFA1) regulating the innate immune responses in mammals

HI Ahmad, FA Khan, MA Khan, S Imran, RW Akhtar… - Genes, 2022 - mdpi.com
Bactericidal/permeability-increasing protein, a primary factor of the innate immune system of
mammals, participates in natural immune protection against invading bacteria. BPIFA1 …

On the saliva proteome of the Eastern European house mouse (Mus musculus musculus) focusing on sexual signalling and immunity

P Stopka, B Kuntová, P Klempt, L Havrdová… - Scientific Reports, 2016 - nature.com
Chemical communication is mediated by sex-biased signals abundantly present in the urine,
saliva and tears. Because most studies concentrated on the urinary signals, we aimed to …

[HTML][HTML] Molecular biology of BPIFB1 and its advances in disease

J Li, P Xu, L Wang, M Feng, D Chen… - Annals of Translational …, 2020 - ncbi.nlm.nih.gov
Abstract Bactericidal/permeability-increasing (BPI)-fold-containing family B member 1
(BPIFB1), also known as long-palate lung and nasal epithelium clone 1 (LPLUNC1) …

An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection

KM Akram, NA Moyo, GH Leeming, L Bingle… - Mucosal …, 2018 - nature.com
The airway epithelium secretes proteins that function in innate defense against infection.
Bactericidal/permeability-increasing fold-containing family member A1 (BPIFA1) is secreted …

An in vitro model of murine middle ear epithelium

A Mulay, KM Akram, D Williams… - Disease Models & …, 2016 - journals.biologists.com
Otitis media (OM), or middle ear inflammation, is the most common paediatric disease and
leads to significant morbidity. Although understanding of underlying disease mechanisms is …

Intense light-elicited alveolar type 2-specific circadian PER2 protects from bacterial lung injury via BPIFB1

Y Oyama, SR Shuff, N Burns… - American Journal of …, 2022 - journals.physiology.org
Circadian amplitude enhancement has the potential to be organ protective but has not been
studied in acute lung injury (ALI). Consistent light and dark cycles are crucial for the …