New technologies for analysis of extracellular vesicles

H Shao, H Im, CM Castro, X Breakefield… - Chemical …, 2018 - ACS Publications
Extracellular vesicles (EVs) are diverse, nanoscale membrane vesicles actively released by
cells. Similar-sized vesicles can be further classified (eg, exosomes, microvesicles) based …

Extracellular vesicles and intercellular communication within the nervous system

V Zappulli, KP Friis, Z Fitzpatrick… - The Journal of …, 2016 - Am Soc Clin Investig
Extracellular vesicles (EVs, including exosomes) are implicated in many aspects of nervous
system development and function, including regulation of synaptic communication, synaptic …

Human CNS barrier-forming organoids with cerebrospinal fluid production

L Pellegrini, C Bonfio, J Chadwick, F Begum, M Skehel… - Science, 2020 - science.org
INTRODUCTION The choroid plexus is a secretory epithelial tissue of the central nervous
system (CNS) responsible for cerebrospinal fluid (CSF) production and functions as a barrier …

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

H Shao, J Chung, K Lee, L Balaj, C Min… - Nature …, 2015 - nature.com
Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical
problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O6 …

Emerging roles of extracellular vesicles in the nervous system

L Rajendran, J Bali, MM Barr… - Journal of …, 2014 - Soc Neuroscience
Information exchange executed by extracellular vesicles, including exosomes, is a newly
described form of intercellular communication important in the development and physiology …

[HTML][HTML] The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications

Y Lei, H Han, F Yuan, A Javeed, Y Zhao - Progress in neurobiology, 2017 - Elsevier
Although neurons attract the most attention in neurobiology, our current knowledge of neural
circuit can only partially explain the neurological and psychiatric conditions of the brain …

LncRNA TUG1 acts as a tumor suppressor in human glioma by promoting cell apoptosis

J Li, M Zhang, G An, Q Ma - Experimental Biology and …, 2016 - journals.sagepub.com
Previous studies have revealed multiple functional roles of long non-coding RNA taurine
upregulated gene 1 in different types of malignant tumors, except for human glioma. Here, it …

Heparin affinity purification of extracellular vesicles

L Balaj, NA Atai, W Chen, D Mu, BA Tannous… - Scientific reports, 2015 - nature.com
Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active
biomolecules including DNA, RNA and protein which can be transferred to recipient cells …

Establishment of age group classification for risk stratification in glioma patients

Z Lin, R Yang, K Li, G Yi, Z Li, J Guo, Z Zhang… - BMC neurology, 2020 - Springer
Background Age is associated with the prognosis of glioma patients, but there is no uniform
standard of age-group classification to evaluate the prognosis of glioma patients. In this …

Circulating biomarkers for gliomas

M Westphal, K Lamszus - Nature Reviews Neurology, 2015 - nature.com
Currently, gliomas are diagnosed by neuroimaging, and refined diagnosis requires
resection or biopsy to obtain tumour tissue for histopathological classification and grading …