The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …

Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …

Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …

Background—A variety of studies carried out using either human subjects or laboratory
animals suggest that vitamin D and its analogues possess important beneficial activity in the …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Calcineurin is a calcium activated protein phosphatase with a major role in calcium
signaling in diverse cells and organs and clinical importance as the target of the …

During the past decade, single gene disruption in mice and large-scale mutagenesis
screens in zebrafish have elucidated many fundamental genetic pathways that govern early …