Clinical utility of EEG in diagnosing and monitoring epilepsy in adults

WO Tatum, G Rubboli, PW Kaplan, SM Mirsatari… - Clinical …, 2018 - Elsevier
Electroencephalography (EEG) remains an essential diagnostic tool for people with epilepsy
(PWE). The International Federation of Clinical Neurophysiology produces new guidelines …

Large scale brain models of epilepsy: dynamics meets connectomics

MP Richardson - Journal of Neurology, Neurosurgery & Psychiatry, 2012 - jnnp.bmj.com
The brain is in a constant state of dynamic change, for example switching between cognitive
and behavioural tasks, and between wakefulness and sleep. The brains of people with …

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

S Larivière, J Royer, R Rodríguez-Cruces… - Nature …, 2022 - nature.com
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

Altered functional–structural coupling of large-scale brain networks in idiopathic generalized epilepsy

Z Zhang, W Liao, H Chen, D Mantini, JR Ding, Q Xu… - Brain, 2011 - academic.oup.com
The human brain is a large-scale integrated network in the functional and structural domain.
Graph theoretical analysis provides a novel framework for analysing such complex …

Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

S Larivière, R Rodríguez-Cruces, J Royer… - Science …, 2020 - science.org
Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-
analysis, we integrated neuroimaging and connectome analysis to identify network …

Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain

J Gotman, C Grova, A Bagshaw… - Proceedings of the …, 2005 - National Acad Sciences
Our objective was to evaluate the brain regions showing increased and decreased
metabolism in patients at the time of generalized bursts of epileptic discharges in order to …

[HTML][HTML] Molecular targets for antiepileptic drug development

BS Meldrum, MA Rogawski - Neurotherapeutics, 2007 - Elsevier
This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

Cellular and network mechanisms of spike‐wave seizures

H Blumenfeld - Epilepsia, 2005 - Wiley Online Library
Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform
defect present in all patients and involvement of the whole brain homogenously. Here, we …

[HTML][HTML] Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks

SG Hormuzdi, MA Filippov, G Mitropoulou… - … et Biophysica Acta (BBA …, 2004 - Elsevier
Gap junctions consist of intercellular channels dedicated to providing a direct pathway for
ionic and biochemical communication between contacting cells. After an initial burst of …

Clinical characteristics, risk factors, and outcomes associated with neonatal hemorrhagic stroke: a population-based case-control study

L Cole, D Dewey, N Letourneau, BJ Kaplan… - JAMA …, 2017 - jamanetwork.com
Importance Hemorrhage into the brain of term newborns often results in major injury and
lifelong disability. The clinical epidemiology of neonatal hemorrhagic stroke (NHS) remains …