HIV-1: to splice or not to splice, that is the question

A Emery, R Swanstrom - Viruses, 2021 - mdpi.com
The transcription of the HIV-1 provirus results in only one type of transcript—full length
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …

Exploring the multifunctionality of SR proteins

I Slišković, H Eich… - Biochemical Society …, 2022 - portlandpress.com
Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

HIV-1 Vpr induces ciTRAN to prevent transcriptional repression of the provirus

V Bhardwaj, A Singh, A Choudhary, R Dalavi… - Science …, 2023 - science.org
The functional consequences of circular RNA (circRNA) expression on HIV-1 replication are
largely unknown. Using a customized protocol involving direct RNA nanopore sequencing …

The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal …

F Roesmann, H Sertznig, K Klaassen… - Journal of …, 2024 - Am Soc Microbiol
The interplay between host factors and viral components impacts viral replication efficiency
profoundly. Members of the cellular heterogeneous nuclear ribonucleoprotein family …

Insights into established and emerging roles of SR protein family in plants and animals

K Kumar, SK Sinha, U Maity, PB Kirti… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …

[HTML][HTML] Towards understandings of serine/arginine-rich splicing factors

D Li, W Yu, M Lai - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which
regulate splice site recognition and spliceosome assembly during precursor messenger …

The chaperone protein p32 stabilizes HIV-1 Tat and strengthens the p-TEFb/RNAPII/TAR complex promoting HIV transcription elongation

C Li, LP Mori, S Lyu, R Bronson… - Proceedings of the …, 2023 - National Acad Sciences
HIV gene expression is modulated by the combinatorial activity of the HIV transcriptional
activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify …

Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules

CC Kao, Y Nie, S Ren, NTTS De Costa… - … Therapy-Nucleic Acids, 2022 - cell.com
A functional cure of chronic hepatitis B requires eliminating the hepatitis B virus (HBV)-
encoded surface antigen (HBsAg), which can suppress immune responses. STOPS are …

SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

H Sertznig, F Roesmann, A Wilhelm… - Frontiers in …, 2022 - frontiersin.org
Efficient HIV-1 replication depends on balanced levels of host cell components including
cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10) …

View from an mRNP: the roles of SR proteins in assembly, maturation and turnover

M Wegener, M Müller-McNicoll - The Biology of mRNA: Structure and …, 2019 - Springer
Serine-and arginine-rich proteins (SR proteins) are a family of multitasking RNA-binding
proteins (RBPs) that are key determinants of messenger ribonucleoprotein (mRNP) …