Recently there has been a keen interest in the statistical analysis of change point detec tion
and estimation. Mainly, it is because change point problems can be encountered in many …

Array comparative genomic hybridization (array CGH) is a method used to detect segmental
DNA copy number alterations. Recently, advances in this technology have enabled high …

Personalised management of cancer means the prescription of specific therapeutics that are
best suited for an individual patient and the type of tumour. Molecular diagnostics influences …

We apply the “fused lasso” regression method of (TSRZ2004) to the problem of “hot-spot
detection”, in particular, detection of regions of gain or loss in comparative genomic …

Adaptive evolution is generally assumed to progress through the accumulation of beneficial
mutations. However, as deleterious mutations are common in natural populations, they …

Abstract Motivation: Array Comparative Genomic Hybridization (CGH) can reveal
chromosomal aberrations in the genomic DNA. These amplifications and deletions at the …

Motivation: Array comparative genomic hybridization (CGH) allows detection and mapping
of copy number of DNA segments. A challenge is to make inferences about the copy number …

Populus has become an important model plant system. However, utilization of the
increasingly extensive collection of genetics and genomics data created by the community is …

Motivation: Knowing the exact locations of multiple change points in genomic sequences
serves several biological needs, for instance when data represent aCGH profiles and it is of …

Motivation: The ability to detect regions of genetic alteration is of great importance in cancer
research. These alterations can take the form of large chromosomal gains and losses as …