The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus
and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic …

It has only recently been appreciated that the human body contains many long-lived proteins
(LLPs). Their gradual degradation over time contributes to human aging and probably also …

Lamins are structural components of the nuclear lamina (NL) that regulate genome
organization and gene expression, but the mechanism remains unclear. Using Hi-C, we …

Deficiencies in either lamin B1 or lamin B2 cause both defective migration of cortical
neurons in the developing brain and reduced neuronal survival. The neuronal migration …

LMNA mutations cause laminopathies that afflict the cardiovascular system and include
Hutchinson-Gilford progeria syndrome. The origins of tissue specificity in these diseases are …

The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria
syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism …

Triclosan (TCS) is a broad spectrum antibacterial agent widely used in personal care
products and present in most aquatic ecosystems. This study investigated the occurrence of …

Genome organization plays a fundamental role in the gene-expression programs of
numerous cell types, but determinants of higher-order genome organization are poorly …

Stem cell homeostasis requires nuclear lamina (NL) integrity. In Drosophila germ cells,
compromised NL integrity activates the ataxia telangiectasia and Rad3-related (ATR) and …

Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D
(PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human …