Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

The steroid hormone aldosterone regulates sodium and potassium homeostasis.
Aldosterone and activation of the mineralocorticoid receptor also causes inflammation and …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

The causes of essential hypertension remain an enigma. Interactions between genetic and
external factors are generally recognized to act as aetiological mechanisms that trigger the …

Primary aldosteronism (PA) is a pathological condition characterized by an excessive
aldosterone secretion; once thought to be rare, PA is now recognized as the most common …

The present study was designed to assess both preventive and therapeutic effects of (S)-1-
(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl) phenyl]-5-[2-(trifluoromethyl) phenyl]-1H …

Steroids have a wide spectrum of impact, serving as fundamental regulators of nearly every
physiological process within the human body. Therapeutic applications of steroids are …

Fifty years ago, Lewis K. Dahl has presented a new model of salt hypertension–salt-
sensitive and salt-resistant Dahl rats. Twenty years later, John P. Rapp has published the …

Abstract Purpose of Review Acute psychoemotional stress is one of the causes of a sharp
increase in blood pressure. However, the question if the stress may promote the …

Identification of key genes in coronary artery disease: an integrative approach based on
weighted gene co-expression network analysis and their correlation with immune infiltration …