I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …

Entangling and twisting of cellular DNA (ie, supercoiling) are problems inherent to the
helical structure of double-stranded DNA. Supercoiling affects transcription, DNA replication …

The displacement loop (D loop) is the product of homology search and DNA strand invasion,
constituting a central intermediate in homologous recombination (HR). In eukaryotes, the …

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in
bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can …

Bacterial chromosomes are organized in replichores of opposite sequence polarity. This
conserved feature suggests a role in chromosome dynamics. Indeed, sequence polarity …

Multimeric, ring-shaped molecular motors rely on the coordinated action of their subunits to
perform crucial biological functions. During these tasks, motors often change their operation …

Since the fundamental discovery of the giant magnetoresistance many spintronic devices
have been developed and implemented in our daily life (eg information storage and …

The separation and segregation of newly replicated bacterial chromosomes can be
constrained by the formation of circular chromosome dimers caused by crossing over during …

The study of chromosome segregation in bacteria has gained strong insights from the use of
cytology techniques. A global view of chromosome choreography during the cell cycle is …

The Snf2 family represents a functionally diverse class of ATPase sharing the ability to
modify DNA structure. Here, we use a magnetic trap and an atomic force microscope to …