Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases,
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …

Although regenerative medicine is searching for pluripotent stem cells that could be
employed for therapy, various types of more differentiated adult stem and progenitor cells …

G-CSF was among the first cytokines to be identified and rapidly transitioned into clinical
medicine. Initially used to promote the production of neutrophils in patients with …

Sphingolipids comprise a complex family of naturally occurring molecules that are enriched
in lipid rafts and contribute to their unique biochemical properties. Membrane sphingolipids …

Activation of the complement system is a major pathogenic event that drives various
inflammatory responses in numerous diseases. All pathways of complement activation lead …

Abstract Transplantation with 2-5× 106 mobilized CD34+ cells/kg body weight lowers
transplantation costs and mortality. Mobilization is most commonly performed with …

Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone
marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic …

Accumulating laboratory studies have implicated the mobilization of bone marrow (BM)-
derived stem cells in brain plasticity and stroke therapy. This mobilization of bone cells to the …

Under normal conditions, the great majority of hematopoietic stem/progenitors cells (HSPCs)
reside in the bone marrow. The number of HSPCs in the circulation can be markedly …

CD44 is an adhesion molecule that varies in size due to glycosylation and insertion of so-
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …