Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …

During the past decade, genome‐wide association studies (GWAS) have transformed our
understanding of many heritable traits. Three recent large‐scale GWAS meta‐analyses now …

Background: Both lifestyle and genetic factors confer risk for cardiovascular diseases, type 2
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …

Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …

Cardiovascular diseases (CVD) annually take almost 18 million lives worldwide. Most lethal
events occur months or years after the initial presentation. Indeed, many patients experience …

Background Large medical centers in urban areas, like Los Angeles, care for a diverse
patient population and offer the potential to study the interplay between genetic ancestry and …

Background Cardiovascular diseases are the leading cause of death in the United States,
yet a significant proportion of adults at high risk remain undetected by standard screening …

A steady rise in cardiovascular morbidity and mortality has been observed in young adults
within the last decades. This trend corresponds to an increasing prevalence of traditional …

Pharmaceutical companies have increasingly utilized genomic data for the selection of drug
targets and the development of precision medicine approaches. Most major pharmaceutical …

Aims Coronary artery disease (CAD) is multifactorial, caused by complex pathophysiology,
and contributes to a high burden of mortality worldwide. Urinary proteomic analyses may …