During the past 6 years, there have been substantial advances in our understanding of
human immunodeficiency virus 1 and other viruses, such as hepatitis B virus and hepatitis C …

In this article, we summarize the role of CD8+ T cells during natural and antiretroviral
therapy (ART)‐treated HIV and SIV infections, discuss the mechanisms responsible for their …

To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV)
replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 …

Some rare HIV-1-infected individuals, referred to as HIV controllers (HIC), have persistently
undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication …

During primary HIV infection the viral load in plasma increases, reaches a peak, and then
declines. Phillips has suggested that the decline is due to a limitation in the number of cells …

BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by
proliferating while avoiding immune recognition. Integration features of intact proviruses in …

Antimicrobial peptides are effectors of innate immunity, providing their hosts with rapid non-
specific defence against parasitic invaders. In this report, the effects are assessed of two well …

It has been known since 1986 that CD8 T lymphocytes from certain HIV-1–infected
individuals who are immunologically stable secrete a soluble factor, termed CAF, that …

Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected
individuals have been demonstrated to suppress viral replication, the mechanisms of …

Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease
following human immunodeficiency virus (HIV) infection. This antiviral response, mediated …