Molecular link between DNA damage response and microtubule dynamics

JM Kim - International journal of molecular sciences, 2022 - mdpi.com
Microtubules are major components of the cytoskeleton that play important roles in cellular
processes such as intracellular transport and cell division. In recent years, it has become …

Microtubule‐associated proteins and enzymes modifying tubulin

N Peng, F Nakamura - Cytoskeleton, 2023 - Wiley Online Library
Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

ß-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1 …

X Chang, Y Li, J Liu, Y Wang, X Guan, Q Wu, Y Zhou… - Phytomedicine, 2023 - Elsevier
Abstract Background TYHX-Tongyang Huoxue decoction has been used clinically for nearly
40 years. The ingredients of TYHX are Radix Astragali (Huangqi), Red Ginseng (Hongshen) …

Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics

T DeSpenza Jr, A Singh, G Allington, S Zhao… - Proceedings of the …, 2024 - pnas.org
Enlargement of the cerebrospinal fluid (CSF)–filled brain ventricles (cerebral
ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly …

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

TJ Attard, JPI Welburn, JA Marsh - PLOS Computational Biology, 2022 - journals.plos.org
Cells rely heavily on microtubules for several processes, including cell division and
molecular trafficking. Mutations in the different tubulin-α and-β proteins that comprise …

The tubulin superfamily in apicomplexan parasites

N Morrissette, I Abbaali, C Ramakrishnan, AB Hehl - Microorganisms, 2023 - mdpi.com
Microtubules and specialized microtubule-containing structures are assembled from
tubulins, an ancient superfamily of essential eukaryotic proteins. Here, we use bioinformatic …

Coevolution of rumen epithelial circRNAs with their microbiota and metabolites in response to cold-season nutritional stress in Tibetan sheep

X Guo, Y Sha, X Pu, Y Xu, L Yao, X Liu, Y He… - International Journal of …, 2022 - mdpi.com
This study explores the effects of the coevolution of the host genome (the first genome) and
gut microbiome (the second genome) on nutrition stress in Tibetan sheep during the cold …

TEDC2 plays an oncogenic role and serves as a therapeutic target of hepatocellular carcinoma

Y Li, B Guo, L Wang, F Zhou, Z Yu, Y Huang… - Digestive and Liver …, 2024 - Elsevier
Background Hepatocellular carcinoma (HCC) is one of the most common malignancies and
tends to have a poor prognosis due to its insidious onset, difficulty in early diagnosis, and …

Biallelic mutations in KATNAL2 cause male infertility due to oligo‐astheno‐teratozoospermia

X Wei, W Liu, X Zhu, Y Li, X Zhang, J Chen… - Clinical …, 2021 - Wiley Online Library
Abstract Oligo‐astheno‐teratozoospermia (OAT) is a common cause of male infertility, and
most of idiopathic OAT patients are thought to be caused by genetic defects. Here, we …

Epsilon tubulin is an essential determinant of microtubule-based structures in male germ cells

GG Stathatos, DJ Merriner, AE O'Connor, J Zenker… - EMBO …, 2024 - embopress.org
Alpha, beta, and gamma tubulins are essential building blocks for all eukaryotic cells. The
functions of the non-canonical tubulins, delta, epsilon, and zeta, however, remain poorly …