[HTML][HTML] Nanoparticle-based radiosensitization strategies for improving radiation therapy

H Shen, H Huang, Z Jiang - Frontiers in Pharmacology, 2023 - frontiersin.org
Radiotherapy remains the mainstay treatment for a variety of cancer forms. However, the
therapeutic efficiency of radiation is significantly limited by several aspects, including high …

[HTML][HTML] Nanomedicine-based multimodal therapies: Recent progress and perspectives in colon cancer

YC He, ZN Hao, Z Li, DW Gao - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Colon cancer has attracted much attention due to its annually increasing incidence.
Conventional chemotherapeutic drugs are unsatisfactory in clinical application because of …

Biodegradable copper-iodide clusters modulate mitochondrial function and suppress tumor growth under ultralow-dose X-ray irradiation

X Ma, N Lin, Q Yang, P Liu, H Ding, M Xu, F Ren… - Nature …, 2024 - nature.com
Abstract Both copper (Cu2+/+) and iodine (I−) are essential elements in all living organisms.
Increasing the intracellular concentrations of Cu or I ions may efficiently inhibit tumor growth …

One Stone, Two Birds: A Peptide‐Au (I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation …

J Wang, J Zhao, F Ma, L Gong, Y Lu, W Xiao, H Tang… - Small, 2023 - Wiley Online Library
Over half of cancer patients are subjected to radiotherapy, but owing to the deficient amount
of reactive oxygen radicals (ROS) and DNA double‐strand breaks (DSBs), a fair number of …

Upconverting Nanoparticles Coated with Light-Breakable Mesoporous Silica for NIR-Triggered Release of Hydrophobic Molecules

V Tam, P Picchetti, Y Liu, A Skripka… - … Applied Materials & …, 2024 - ACS Publications
Upconverting nanoparticles (UCNPs) doped with Yb3+ and Tm3+ are near-infrared (NIR) to
ultraviolet (UV) transducers that can be used for NIR-controlled drug delivery. However, due …

Empowering radiotherapy: Harnessing nanomedicines to enhance radiation response and boost antitumor efficacy

X Zhuo, R Aishajiang, Y Liang, P Du, P Lei, D Yu… - Coordination Chemistry …, 2024 - Elsevier
Radiotherapy (RT) is a conventional form of tumor treatment that uses X-ray irradiation to
eliminate tumors. Although RT plays an important role in treating tumor patients and …

The drug release of PLGA-based nanoparticles and their application in treatment of gastrointestinal cancers

R Sun, Y Chen, Y Pei, W Wang, Z Zhu, Z Zheng… - Heliyon, 2024 - cell.com
The poly (lactic-co-glycolic acid)(PLGA) based nanoparticles have been applied for drug
delivery due to their simple preparation, biodegradability, and ideal biocompatibility. In this …

An acid-activatable fluorouracil prodrug for colorectal cancer synergistic therapy

X Ma, N Lin, K Hu, C Xu, Q Yang, Y Feng, P Liu… - Acta Biomaterialia, 2024 - Elsevier
Fluorouracil has demonstrated certain efficiency in patients with colorectal cancer. However,
significant side effects of use by injection are common. To address this issue defects, a …

[HTML][HTML] Abnormal changes in metabolites caused by m6A methylation modification: The leading factors that induce the formation of immunosuppressive tumor …

L Zhao, J Guo, S Xu, M Duan, B Liu, H Zhao… - Journal of Advanced …, 2024 - Elsevier
Abstract Background N6-methyladenosine (m 6 A) RNA methylation modifications have
been widely implicated in the metabolic reprogramming of various cell types within the tumor …

Advances in nanoparticle-based radiotherapy for cancer treatment

MJ He, SX Chen, HW Yu, XH Fan, H Wu, YH Wang… - iScience, 2024 - cell.com
Radiotherapy has long been recognized as an effective conventional approach in both
clinical and scientific research, primarily through mechanisms involving DNA destruction or …