Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Tumour recurrence is a serious impediment to cancer treatment, but the mechanisms
involved are poorly understood. The most frequently used anti-tumour therapies …

The BCL-2/BCL-XL/BCL-W inhibitor ABT-263 (navitoclax) has shown promising clinical
activity in lymphoid malignancies such as chronic lymphocytic leukemia. However, its …

The biological complexity of cancer represents a tremendous clinical challenge, resulting in
the frequent failure of current treatment protocols. In the rapidly evolving scenario of a …

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …

Resistance to tumor therapy is an unsolved problem in cancer treatment. A plethora of
studies have attempted to explain this phenomenon and many mechanisms of resistance …

Metabolic reprogramming has been described in rapidly growing tumors, which are thought
to mostly contain fast‐cycling cells (FCC s) that have impaired mitochondrial function and …

Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

An abnormal multicellular architecture is a defining characteristic of breast cancer and, yet,
most in vitro tumor models fail to recapitulate this architecture or accurately predict in vivo …