Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation-
induced DNA double-strand breaks (DSBs) in human cells and is essential for the …

Members of the phosphatidylinositol 3ʹ kinase (PI3K)-related kinases (PIKKs) family,
including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), ataxia telangiectasia …

DNA double-stranded breaks (DSBs) are a particularly challenging form of DNA damage to
repair because the damaged DNA must not only undergo the chemical reactions …

The proteins and protein assemblies involved in DNA repair have been the focus of a
multitude of structural studies for the past few decades. Historically, the structures of these …

Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-
stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in …

DNA double strand breaks (DSBs) are common lesions whose misrepair are drivers of
oncogenic transformations. The non-homologous end joining (NHEJ) pathway repairs the …

The complex formed by Ku70/80 and DNA-PKcs (DNA-PK) promotes the synapsis and the
joining of double strand breaks (DSBs) during canonical non-homologous end joining (c …

In the ciliate Paramecium, precise excision of numerous internal eliminated sequences
(IESs) from the somatic genome is essential at each sexual cycle. DNA double-strands …

The deployment of DNA damage response (DDR) combats various forms of DNA damage,
ensuring genomic stability. Cancer cells' propensity for genomic instability offers therapeutic …

Given its central role in life, DNA is remarkably easy to damage. Double strand breaks
(DSBs) are the most toxic form of DNA damage, and DSBs pose the greatest danger to …