Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay: Miniperspective

GF Pauli, SN Chen, C Simmler, DC Lankin… - Journal of medicinal …, 2014 - ACS Publications
In any biomedical and chemical context, a truthful description of chemical constitution
requires coverage of both structure and purity. This qualification affects all drug molecules …

Quantitative 1H NMR. Development and Potential of an Analytical Method: An Update

GF Pauli, T Godecke, BU Jaki… - Journal of natural …, 2012 - ACS Publications
Covering the literature from mid-2004 until the end of 2011, this review continues a previous
literature overview on quantitative 1H NMR (qHNMR) methodology and its applications in …

Quantitative NMR spectroscopy in pharmaceutical applications

U Holzgrabe - Progress in Nuclear Magnetic Resonance …, 2010 - Elsevier
1H and 13C NMR spectroscopy is routinely used for the elucidation of structures of newly
synthesized compounds, natural products and semi-synthesized compounds. The …

Research progress of NMR in natural product quantification

ZF Wang, YL You, FF Li, WR Kong, SQ Wang - Molecules, 2021 - mdpi.com
In the fields of medicine and health, traditional high-performance liquid chromatography or
UV-visible spectrophotometry is generally used for substance quantification. However, over …

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?

DC Holland, AR Carroll - Natural Product Reports, 2023 - pubs.rsc.org
Covering: marine indole alkaloids (n= 2048) and their reported bioactivities up to the end of
2021 Despite increasing numbers of marine natural products (MNPs) reported each year …

HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case

JG Napolitano, DC Lankin, TN Graf… - The Journal of …, 2013 - ACS Publications
This study demonstrates how regio-and diastereo-isomers with near-identical NMR spectra
can be distinguished and unambiguously assigned using quantum mechanical driven 1H …

Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases

RA Davis, A Hofmann, A Osman, RA Hall… - Journal of Medicinal …, 2011 - ACS Publications
In order to discover novel probes that may help in the investigation and control of infectious
diseases through a new mechanism of action, we have evaluated a library of phenol-based …

Skyllamycins D and E, Non-Ribosomal Cyclic Depsipeptides from Lichen-Sourced Streptomyces anulatus

J Bracegirdle, P Hou, VV Nowak… - Journal of Natural …, 2021 - ACS Publications
The skyllamycins are a class of heavily modified, non-ribosomal peptides, first isolated from
Streptomyces sp. KY11784. A Streptomyces strain with potent antibiotic activity against …

Validation of a Generic Quantitative 1H NMR Method for Natural Products Analysis

T Gödecke, JG Napolitano… - Phytochemical …, 2013 - Wiley Online Library
Introduction Nuclear magnetic resonance (NMR) spectroscopy is increasingly employed in
the quantitative analysis and quality control (QC) of natural products (NP) including …

Reference and normalization methods: Essential tools for the intercomparison of NMR spectra

P Giraudeau, I Tea, GS Remaud, S Akoka - Journal of pharmaceutical and …, 2014 - Elsevier
This review aims at providing an analysis of the various available reference methods in
nuclear magnetic resonance, based on recent literature. This paper will provide a tool to …