Structure and function of the nuclear pore complex

S Petrovic, GW Mobbs, CJ Bley… - Cold Spring …, 2022 - cshperspectives.cshlp.org
The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

The nuclear pore complex: birth, life, and death of a cellular behemoth

E Dultz, M Wojtynek, O Medalia, E Onischenko - Cells, 2022 - mdpi.com
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

AI-based structure prediction empowers integrative structural analysis of human nuclear pores

S Mosalaganti, A Obarska-Kosinska, M Siggel… - Science, 2022 - science.org
INTRODUCTION The eukaryotic nucleus protects the genome and is enclosed by the two
membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear …

Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold

P Fontana, Y Dong, X Pi, AB Tong, CW Hecksel… - Science, 2022 - science.org
INTRODUCTION The nuclear pore complex (NPC) is the molecular conduit in the nuclear
membrane of eukaryotic cells that regulates import and export of biomolecules between the …

Lipid saturation controls nuclear envelope function

A Romanauska, A Köhler - Nature Cell Biology, 2023 - nature.com
The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE
shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …

Visualizing the disordered nuclear transport machinery in situ

M Yu, M Heidari, S Mikhaleva, PS Tan, S Mingu… - Nature, 2023 - nature.com
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper
for the transport between the nucleus and cytosol. The central channel of the NPC is filled …

Architecture of the linker-scaffold in the nuclear pore

S Petrovic, D Samanta, T Perriches, CJ Bley… - Science, 2022 - science.org
INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …

Implications of a multiscale structure of the yeast nuclear pore complex

CW Akey, I Echeverria, C Ouch, I Nudelman, Y Shi… - Molecular Cell, 2023 - cell.com
Nuclear pore complexes (NPCs) direct the nucleocytoplasmic transport of macromolecules.
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …

Docking a flexible basket onto the core of the nuclear pore complex

E Stankunas, A Köhler - Nature Cell Biology, 2024 - nature.com
The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC),
coupling transcription to mRNA quality control and export. The basket expands the …

The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores

Q Shen, S Kumari, C Xu, S Jang, J Shi… - Proceedings of the …, 2023 - National Acad Sciences
Increasing evidence has suggested that the HIV-1 capsid enters the nucleus in a largely
assembled, intact form. However, not much is known about how the cone-shaped capsid …