Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …

Angiopoietin-like protein (ANGPTL) 3 regulates plasma lipids by inhibiting LPL and
endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in
cardiovascular disease has been widely studied, only recently the role of other members of …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

WNT signaling controls many biological processes including cell differentiation in
metazoans. However, how WNT reprograms cell identity is not well understood. We have …

Osteoblasts and adipocytes differentiate from a common pluripotent precursor, the
mesenchymal stem cell (MSC). Studies have identified numerous transcription factors, and …