The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …

A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …

Addressing MRSA infection and antibacterial resistance with peptoid polymers

J Xie, M Zhou, Y Qian, Z Cong, S Chen… - Nature …, 2021 - nature.com
Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for
antibacterial agents that are not prone to antimicrobial resistance. We prepare protease …

Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

Carbon-based nanomaterials: promising antiviral agents to combat COVID-19 in the microbial-resistant era

Á Serrano-Aroca, K Takayama, A Tuñón-Molina… - ACS …, 2021 - ACS Publications
Therapeutic options for the highly pathogenic human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID …

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

J Wang, X Dou, J Song, Y Lyu, X Zhu… - Medicinal research …, 2019 - Wiley Online Library
Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely
distributed throughout the animal and plant kingdoms. They can protect against a broad …

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

[HTML][HTML] Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Á Serrano-Aroca, A Cano-Vicent, RS i Serra… - Materials Today Bio, 2022 - Elsevier
Due to microbial infections dramatically affect cell survival and increase the risk of implant
failure, scaffolds produced with antimicrobial materials are now much more likely to be …

Poly (2‐Oxazoline)‐based functional peptide mimics: Eradicating MRSA infections and persisters while alleviating antimicrobial resistance

M Zhou, Y Qian, J Xie, W Zhang… - Angewandte Chemie …, 2020 - Wiley Online Library
Peptides have important biological functions. However, their susceptibility to proteolysis
limits their applications. We demonstrated here for the first time, that poly (2 …