The past decade has seen a tremendous increase in interest and progress in the field of
sperm epigenetics. Studies have shown that chromatin regulation during male germline …

Understanding how DNA is packaged in the mammalian sperm cell has important
implications for human infertility as well as for the cell biology. Recent advances in the study …

Comparative genomics and systems biology offer unprecedented opportunities for testing
central tenets of evolutionary biology formulated by Darwin in the Origin of Species in 1859 …

Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

We studied the nuclear topography of RNA transcription and DNA replication in mammalian
cell types with super-resolution fluorescence microscopy, which offers a resolution beyond …

The nuclear matrix is a nuclear compartment that has diverse functions in chromatin
regulation and transcription. However, how this structure influences epigenetic modifications …

The bHLH proteins are a family of eukaryotic transcription factors regulating expression of a
wide range of genes involved in cell differentiation and development. They contain the Helix …

Sperm present a highly particular DNA condensation that is acquired during their
differentiation. Protamines are key elements for DNA condensation. However, whereas the …

Lamin A-related progeroid syndromes are genetically determined, extremely rare and
severe. In the past ten years, our knowledge and perspectives for these diseases has widely …

There is an extensive list of primary published work related to the nuclear matrix (NM). Here
we review the aspects that are required to understand its relationship with DNA replication …