Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Gene expression patterns in complex multicellular organisms are regulated by enhancers,
which communicate with their target gene promoters in three-dimensional (3D) chromatin …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

From proteins to chromosomes, polymers fold into specific conformations that control their
biological function. Polymer folding has long been studied with equilibrium thermodynamics …

Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …

RNA polymerase II initiates transcription either randomly or in bursts. We examined the light-
dependent transcriptional activator White Collar Complex (WCC) of Neurospora to …

Inside human nuclei, genes are transcribed within a highly packed genome, whose
organization is facilitated by cohesin-mediated loop extrusion. However, whether cohesin …

Transcriptional enhancers must find their target genes both efficiently and specifically.
Chromatin conformation capture revealed the critical function of three-dimensional …

In mammalian cells, the cohesin protein complex is believed to translocate along chromatin
during interphase to form dynamic loops through a process called active loop extrusion …