Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Advances in the synthesis and screening of small-molecule libraries have accelerated the
discovery of chemical probes for studying biological processes. Still, only a small fraction of …

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …

RAF kinases are essential effectors of RAS, but how RAS binding initiates the
conformational changes needed for autoinhibited RAF monomers to form active dimers has …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

Pyrin, encoded by the MEFV gene, is best known for its gain-of-function mutations causing
familial Mediterranean fever (FMF), an autoinflammatory disease. Pyrin forms a caspase-1 …

The 14-3-3 proteins, a family of conserved regulatory molecules, participate in a wide range
of cellular processes through binding interactions with hundreds of structurally and …

More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define
14-3-3 specificities, identify relevant protein kinases, and give insights into how cellular 14-3 …

14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed
in all eukaryotic cells. These proteins participate in a variety of intracellular processes by …