Oxidative stressrelated mechanisms in schizophrenia pathogenesis and new treatment perspectives

EA Ermakov, EM Dmitrieva… - Oxidative Medicine …, 2021 - Wiley Online Library
Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

NN Parikshak, MJ Gandal, DH Geschwind - Nature Reviews Genetics, 2015 - nature.com
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

B Devlin, JR Kelsoe, P Sklar, MJ Daly… - Nature …, 2015 - nature.com
Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …

Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data

Q Yang, B Li, J Tang, X Cui, Y Wang, X Li… - Briefings in …, 2020 - academic.oup.com
The etiology of schizophrenia (SCZ) is regarded as one of the most fundamental puzzles in
current medical research, and its diagnosis is limited by the lack of objective molecular …

[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Auditory dysfunction in schizophrenia: integrating clinical and basic features

DC Javitt, RA Sweet - Nature Reviews Neuroscience, 2015 - nature.com
Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent
psychosocial disability in affected individuals. Although studies of schizophrenia have …

Evolution of the neocortex: a perspective from developmental biology

P Rakic - Nature Reviews Neuroscience, 2009 - nature.com
The enlargement and species-specific elaboration of the cerebral neocortex during
evolution holds the secret to the mental abilities of humans; however, the genetic origin and …

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

SG Fillman, N Cloonan, VS Catts, LC Miller… - Molecular …, 2013 - nature.com
Upregulation of the immune response may be involved in the pathogenesis of schizophrenia
with changes occurring in both peripheral blood and brain tissue. To date, microarray …

Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring

KE Stephan, KJ Friston, CD Frith - Schizophrenia bulletin, 2009 - academic.oup.com
Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …