Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer
incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases …

Colorectal cancer (CRC) results from the progressive accumulation of genetic and
epigenetic alterations that lead to the transformation of normal colonic mucosa to …

Activities of fast growing human population are altering freshwater ecosystems, endangering
their inhabitants and public health. Organic and trace compounds have a high potential for …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

Most scientists agree that the majority of human solid malignant tumors are characterized by
chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Whereas over 85% of human cancers are solid tumors, of the 8 monoclonal antibodies
(mAbs) currently approved for cancer therapy, 25% are directed at solid tumor surface …

Carcinogenesis is a complex, multistep, multipath process often described as “somatic
evolution”. Conventional models of cancer progression are typically based on the genetic …

Colorectal cancer (CRC) is one of the most common causes of death, despite decades of
research. Initially considered as a disease due to genetic mutations, it is now viewed as a …