1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

The choice of electrode material is critical for achieving optimal yields and selectivity in
synthetic organic electrochemistry. The material imparts significant influence on the kinetics …

As the breadth of radical chemistry grows, new means to promote and regulate single-
electron redox activities play increasingly important roles in driving modern synthetic …

Conspectus Electrochemical organic oxidation reactions are highly appealing because
protons are often effective terminal electron acceptors, thereby avoiding undesirable …

An electrochemical asymmetric coupling of secondary acyclic amines with ketones via a
Shono-type oxidation has been described, affording the corresponding amino acid …

Monitoring reactive intermediates can provide vital information in the study of synthetic
reaction mechanisms, enabling the design of new catalysts and methods. Many synthetic …

The “magic methyl” effect, a dramatic boost in the potency of biologically active compounds
from the incorporation of a single methyl group, provides a simple yet powerful strategy …

Skeletal editing involves making specific point‐changes to the core of a molecule through
the selective insertion, deletion or exchange of atoms. It thus represents a potentially …