Countercurrent separation of natural products: an update

JB Friesen, JB McAlpine, SN Chen… - Journal of natural …, 2015 - ACS Publications
This work assesses the current instrumentation, method development, and applications in
countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC) …

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

LM Leandro, F de Sousa Vargas, PCS Barbosa… - Molecules, 2012 - mdpi.com
Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species
(Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially …

[HTML][HTML] Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus—A review

C Arruda, JAA Mejía, VP Ribeiro, CHG Borges… - Biomedicine & …, 2019 - Elsevier
Copaifera is a genus of large trees found in Brazil, mainly in Amazon forest, but also in
Atlantic forest and cerrado biomes. It has also been found in other countries in South …

Antimicrobial activity of copaiba oil: A review and a call for further research

PL Tobouti, TC de Andrade Martins, TJ Pereira… - Biomedicine & …, 2017 - Elsevier
Copaiba oil has been used for more than 390 years, however, considering the time of
empirical use, there are a scarce number of publications on its activities. This essential oil is …

Antimicrobial and cytotoxic effects of the Copaifera reticulata oleoresin and its main diterpene acids

ALP Barbosa, A Wenzel-Storjohann, JD Barbosa… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance The oleoresin of Brazilian Copaifera reticulata is a
traditional remedy used for the treatment of skin and urinary tract infections, respiratory …

Counter-current chromatography for the separation of terpenoids: a comprehensive review with respect to the solvent systems employed

K Skalicka-Woźniak, I Garrard - Phytochemistry Reviews, 2014 - Springer
Natural products extracts are commonly highly complex mixtures of active compounds and
consequently their purification becomes a particularly challenging task. The development of …

Development of a validated ultra-high-performance liquid chromatography tandem mass spectrometry method for determination of acid diterpenes in Copaifera …

JJM da Silva, EJ Crevelin, LJ Carneiro, H Rogez… - … of Chromatography A, 2017 - Elsevier
Abstract Species of Copaifera genus (Fabaceae–Caesalpinoiodidaeae) produces an
important commercial oleoresin that displays many medicinal properties. Copaifera …

Polyalthic Acid from Copaifera lucens Demonstrates Anticariogenic and Antiparasitic Properties for Safe Use

MB Santiago, VCO Dos Santos, SC Teixeira… - Pharmaceuticals, 2023 - mdpi.com
This study aimed at evaluating the potential of Copaifera lucens, specifically its oleoresin
(CLO), extract (CECL), and the compound ent-polyalthic acid (PA), in combating caries and …

Isolation of cytotoxic diterpenoids from the Chilean medicinal plant Azorella compacta Phil from the Atacama Desert by high‐speed counter‐current chromatography

J Bórquez, NL Bartolucci… - Journal of the …, 2016 - Wiley Online Library
BACKGROUND Azorella compacta (Apiaceae) is a native Chilean cushion shrub which
produces a resin containing mulinane and azorellane diterpenoids. This plant has been …

Quantification of diterpene acids in Copaiba oleoresin by UHPLC-ELSD and heteronuclear two-dimensional qNMR

SS Çiçek, ALP Barbosa, U Girreser - Journal of pharmaceutical and …, 2018 - Elsevier
In this study, we present the quantitation of eight diterpene acids in the oleoresin of
Copaifera reticulata Ducke by UHPLC-ELSD and quantitative HSQC (heteronuclear single …