Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

Once deemed heretical, emerging evidence now supports the notion that the inheritance of
acquired characteristics can occur through ancestral exposures or experiences and that …

The association between poor paternal diet, perturbed embryonic development, and adult
offspring ill health represents a new focus for the Developmental Origins of Health and …

BACKGROUND The best-known role of spermatozoa is to fertilize the oocyte and to transmit
the paternal genome to offspring. These highly specialized cells have a unique structure …

Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …

BACKGROUND Spermatozoa are highly differentiated, transcriptionally inert cells
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …

BACKGROUND Spermatogenesis generates a small and highly specialised type of cell that
is apparently incapable of transcription and translation. For many years, this dogma was …

In mammals, male gametes are produced inside the testis by spermatogenesis, which has
three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid …

Transgenerational epigenetic effects include all processes that have evolved to achieve the
nongenetic determination of phenotype. There has been a long-standing interest in this area …

The most fundamental process for the perpetuation of a species is the transfer of information
from parent to offspring. Although genomic DNA contributes to the majority of the …