This review is a survey of various approaches to targeting cytotoxic anticancer drugs to
tumors primarily through biomolecules expressed by cancer cells or associated vasculature …

1. Little information is available about the pharmacokinetic interactions of anticancer drugs
in man. However, clinically significant drug interactions do occur in cancer chemotherapy …

The concept of overexpression of individual forms of cytochrome P 450 enzymes in tumor
cells is now becoming well recognized. Indeed, a growing body of research highlights the …

Gene therapy of cancer is a novel approach with the potential to selectively eradicate tumour
cells, whilst sparing normal tissue from damage. In particular, gene‐directed enzyme …

Alkylating agents have been used for the treatment of cancer for over six decades, yet their
repertoire continues to grow. These agents act during all phases of the cell cycle, directly on …

The principle of using suicide genes for gene directed enzyme prodrug therapy (GDEPT) of
cancer has gained increasing significance during the 20 years since its inception. The astute …

The extensive exploitation of the antitumor effect of donor lymphocytes infused after
allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is limited by the risk of graft …

Among the broad array of genes that have been evaluated for tumor therapy, those
encoding prodrug activation enzymes are especially appealing as they directly complement …

Herpes simplex viruses type 1 (HSV-1) with an inactivated viral ribonucleotide reductase
(Hsrr, ICP6) were designed to target tumor cells with upregulated mammalian ribonucleotide …

The difficult clinical situation still associated with most types of primary human brain tumors
has fostered significant interest in defining novel therapeutic modalities for this …