Regulation of T cell responses by innate lymphoid cells (ILCs) is increasingly documented
and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

INTERACTIONS between cytokine and receptor lead to the activation of multiple signalling
molecules, including the family of signal transducer and activator of transcription (STAT) …

The large coding potential of vaccinia virus (VV) vectors is a defining feature. However,
limited regulatory switches are available to control viral replication as well as timing and …

Although lacking the components that characterize the acquired immunity systems of
vertebrates, invertebrates nevertheless possess effective general innate immune …

As our understanding of the molecular mechanisms governing natural killer (NK) cell activity
increases, their potential in cancer immunotherapy is growing increasingly prominent. This …

In this paper, we briefly survey the history of concepts in reproductive immunology from
antibody-mediated tolerance to the 'fetal allograft'to the current concept of an embryo …

Abstract Interleukin (IL)-12 plays a critical role in modulating the activities of natural killer
(NK) cells and T lymphocytes. In animal models, IL-12 has potent antitumor effects that are …

CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in
humans, mice, and other species in response to many diverse pathogens. Since CD4 …

Transcription factors have a profound influence on both the differentiation and effector
function of cells of the immune system. T-bet controls the cytotoxicity of CD8+ T cells and the …