Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to
memory loss and cognitive impairment over time. It is characterized by protein misfolding as …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Abstract β-site amyloid precursor protein cleaving enzyme (BACE1) represents a key target
for Alzheimer's disease (AD) therapy because it is essential for producing the toxic amyloid β …

Of all types of dementia, Alzheimer's disease is the type that has the highest proportion of
cases and is the cause of substantial medical and economic burden. The mechanism of …

Aberrant increases in neuronal network excitability may contribute to cognitive deficits in
Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons …

Alzheimer's disease (AD) is a common neurodegenerative disease whose prevalence
increases with age. An increasing number of findings suggest that abnormalities in the …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is currently the
seventh leading cause of death worldwide. It is characterized by the extracellular …

Exploring the potential lead compounds for Alzheimer's disease (AD) remains one of the
challenging tasks. Here, we report that the plant extract conophylline (CNP) impeded …

Amyloidogenesis is one of the key pathophysiological changes in Alzheimer's disease (AD).
Accumulation of the toxic Aβ results from the catalytic processing of β-amyloid precursor …

It is well known that amyloid precursor protein (APP), the enzyme β-secretase 1 (BACE1),
cyclooxygenase 2 (COX-2), nicastrin (NCT), and hyperphosphorylated tau protein (p-tau) …