Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

[HTML][HTML] Dual role of reactive oxygen species and their application in cancer therapy

R Huang, H Chen, J Liang, Y Li, J Yang, C Luo… - Journal of …, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression,
and treatment of cancer. Excess ROS can induce nuclear DNA, leading to cancer initiation …

Capsaicin: A two-decade systematic review of global research output and recent advances against human cancer

TL Adetunji, F Olawale, C Olisah, AE Adetunji… - Frontiers in …, 2022 - frontiersin.org
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products
in the genus Capsicum. Due to its numerous biological effects, there has been extensive …

An overview of novel agents for cervical cancer treatment by inducing apoptosis: Emerging drugs ongoing clinical trials and preclinical studies

L Liu, M Wang, X Li, S Yin, B Wang - Frontiers in medicine, 2021 - frontiersin.org
As the leading cause of cancer death, cervical cancer ranks fourth for both incidence and
mortality. Cervical cancer incidence and mortality rates have reportedly decreased over the …

Bioactive food components for colorectal cancer prevention and treatment: A good match

S Amintas, C Dupin, J Boutin, P Beaumont… - Critical reviews in …, 2023 - Taylor & Francis
Colorectal cancer (CRC) is the third most frequent cancer worldwide, accounts for about
10% of the total cancer cases, and ranks as the second cause of death by cancer. CRC is …

Natural compounds that target DNA repair pathways and their therapeutic potential to counteract cancer cells

FA Lagunas-Rangel, RM Bermúdez-Cruz - Frontiers in Oncology, 2020 - frontiersin.org
Resistance to current cancer treatments is an important problem that arises through various
mechanisms, but one that stands out involves an overexpression of several factors …

[HTML][HTML] Targeting the DNA damage response (DDR) of cancer cells with natural compounds derived from Panax ginseng and other plants

SG Choi, M Shin, WY Kim - Journal of Ginseng Research, 2024 - Elsevier
DNA damage is a driver of cancer formation, leading to the impairment of repair
mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic …

Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1

X Deng, Y Gui, L Zhao, N Li, L Li - Cancer Gene Therapy, 2024 - nature.com
Hepatocellular carcinoma (HCC) is a primary liver cancer with a high mortality rate that
requires research and improved treatment strategies. Chemotherapy is still one of the main …

Facile synthetic nano-curcumin encapsulated Bio-fabricated nanoparticles induces ROS-mediated apoptosis and migration blocking of human lung cancer cells

Y Dong, Y Yang, Y Wei, Y Gao, W Jiang, G Wang… - Process …, 2020 - Elsevier
Lung cancer is one of the major life-threatening cancers, with a higher mortality rate and
morbidity. Curcumin acts as a potential anticancer agent but it shows less aqueous solubility …

9-amino acid cyclic peptide-decorated sorafenib polymeric nanoparticles for the efficient in vitro nursing care analysis of hepatocellular carcinoma

Y Hu, D Yu, X Zhang - Process Biochemistry, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related
mortality worldwide. Sorafenib acts as a potential anticancer agent, but it shows less …