Highlights•RNAi is an important antiviral defense mechanism in insects.•All major classes of
viruses are targets of the antiviral RNAi response.•Viruses encode suppressors that interfere …

RNA has emerged as a revolutionary and important tool in the battle against emerging
infectious diseases, with roles extending beyond its applications in vaccines, in which it is …

ABSTRACT RNA interference (RNAi) is a process of eukaryotic posttranscriptional gene
silencing that functions in antiviral immunity in plants, nematodes, and insects. However …

As an overarching immune mechanism, RNA interference (RNAi) displays pathogen
specificity and memory via different pathways. The small interfering RNA (siRNA) pathway is …

Highlights•Insect RNA interference (RNAi) pathways detect and restrict viruses.•Dicer-2
detects diverse viral dsRNA signatures and initiates the RNAi pathway.•RNAi may play a …

Mosquito-specific viruses (MSVs) are a subset of insect-specific viruses that are found to
infect mosquitoes or mosquito derived cells. There has been an increase in discoveries of …

Cellular organisms have evolved related pathways for the biogenesis and function of small
interfering RNAs (siRNAs), microRNAs and PIWI-interacting RNAs (piRNAs). These distinct …

During the life cycle of mosquito-borne flaviviruses, substantial subgenomic flaviviral RNA
(sfRNA) is produced via incomplete degradation of viral genomic RNA by host XRN1. Zika …

ABSTRACT RNA interference (RNAi) is a conserved antiviral immune defense in
eukaryotes, and numerous viruses have been found to encode viral suppressors of RNAi …

Ebola virus (EBOV) is a non-segmented, negative-sense RNA virus (NNSV) in the family
Filoviridae, and is recognized as one of the most lethal pathogens in the planet. For RNA …