Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …

Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma
and remains incurable in around 40% of patients. Efforts to sequence the coding genome …

Follicular lymphoma (FL) is an indolent disease, but 30%–40% of cases undergo histologic
transformation to an aggressive malignancy, typically represented by diffuse large B cell …

A key feature of the adaptive immune system is the generation of memory B and T cells and
long-lived plasma cells, providing protective immunity against recurring infectious agents …

Germinal centers (GCs) are sites of B-cell clonal expansion, hypermutation, and selection.
GCs are polarized into dark (DZ) and light zones (LZ), a distinction that is of key importance …

This review summarizes recent evidence concerning molecular changes in the commonest
type of lymphoma, diffuse large-B-cell lymphoma. Detailed studies have revealed three …

BCL6 is a transcriptional repressor required in mature B cells during the germinal center
(GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at …

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …