Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Chronic pain is a leading cause of disability globally and associated with enormous health-
care costs. The discrepancy between the extent of tissue damage and the magnitude of …

Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability
worldwide, largely due to pain, the primary symptom of the disease. The pain experience in …

Accurate classification of chronic pain conditions requires reliable and valid pain
assessment. Moreover, pain assessment serves several additional functions, including …

Objective Emerging evidence suggests that pain sensitization plays an important role in pain
associated with knee osteoarthritis (OA). This systematic review and meta-analysis …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Quantitative sensory testing (QST) is a psychophysical method used to quantify
somatosensory function in response to controlled stimuli in healthy subjects and patients …

Pain neuroscience education (PNE) is increasingly used as part of a physical therapy
treatment in patients with chronic pain. A thorough clinical biopsychosocial assessment is …