Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors

A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2023 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

[HTML][HTML] Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

Z Li, M Peng, P Chen, C Liu, A Hu, Y Zhang, J Peng… - Cell Metabolism, 2022 - cell.com
Summary Coronavirus disease 2019 (COVID-19) represents a systemic disease that may
cause severe metabolic complications in multiple tissues including liver, kidney, and …

Potency of Xanthone Derivatives from Garcinia mangostana L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A …

C Suhandi, SS Alfathonah, AN Hasanah - Molecules, 2023 - mdpi.com
ACE2 and Mpro in the pathology of SARS-CoV-2 show great potential in developing COVID-
19 drugs as therapeutic targets, due to their roles as the “gate” of viral entry and viral …

Characterization of passive microfluidic mixer with a three-dimensional zig-zag channel for cryo-EM sampling

B Lee, M Kim, S Oh, DB Lee, SG Lee, HM Kim… - Chemical Engineering …, 2023 - Elsevier
Microfluidic mixing is an essential unit operation in miniaturized analytical systems.
Achieving high mixing efficiency is considerably difficult in conventional microfluidic …

Host cell targets for unconventional antivirals against RNA viruses

VC Roa-Linares, M Escudero-Flórez… - Viruses, 2023 - mdpi.com
The recent COVID-19 crisis has highlighted the importance of RNA-based viruses. The most
prominent members of this group are SARS-CoV-2 (coronavirus), HIV (human …

Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino rats

EM El-Fakharany, H El-Gendi, YA El-Maradny… - International Journal of …, 2023 - Elsevier
Severe acute respiratory syndrome 2019-new coronavirus (SARS-CoV-2) is a major global
challenge caused by a pandemic disease, named 'COVID-19'with no effective and selective …

Botanical inhibitors of SARS-CoV-2 viral entry: a phylogenetic perspective

CJ Risener, S Woo, T Samarakoon, M Caputo… - Scientific Reports, 2023 - nature.com
Throughout the SARS-CoV-2 pandemic, the use of botanical dietary supplements in the
United States has increased, yet their safety and efficacy against COVID-19 remains …

SARS-CoV-2 enters human leydig cells and affects Testosterone Production in Vitro

L Li, CM Sottas, HY Chen, Y Li, H Cui, JS Villano… - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a SARS-like coronavirus,
continues to produce mounting infections and fatalities all over the world. Recent data point …

[PDF][PDF] COVID-19 and neurodegenerative diseases.

YW Fu, HS Xu, SJ Liu - European Review for Medical & …, 2022 - europeanreview.org
OBJECTIVE: The pandemic of Coronavirus Disease 2019 (COVID-19) caused by Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues, and SARS-CoV-2 …