Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Centrosome amplification is a common feature of human tumors, but whether this is a cause
or a consequence of cancer remains unclear. Here, we test the consequence of centrosome …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Centrosomes, the main microtubule-organizing centers in animal cells, are replicated
exactly once during the cell division cycle to form the poles of the mitotic spindle …

Centrosomes are membrane-less organelles that orchestrate a wide array of biological
functions by acting as microtubule organizing centers. Here, we report that caspase-2 …

Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of
human tumors. Enforced centrosome amplification in vivo plays a role in tumor initiation and …

Unscheduled increases in ploidy underlie defects in tissue function, premature aging, and
malignancy. A concomitant event to polyploidization is the amplification of centrosomes, the …