Latest developments in molecular tracers for fluorescence image-guided cancer surgery

S Hernot, L van Manen, P Debie, JSD Mieog… - The lancet …, 2019 - thelancet.com
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

Next generation NIR fluorophores for tumor imaging and fluorescence-guided surgery: A review

A Haque, MSH Faizi, JA Rather, MS Khan - Bioorganic & medicinal …, 2017 - Elsevier
Cancer is a group of diseases responsible for the major causes of mortality and morbidity
among people of all ages. Even though medical sciences have made enormous growth …

Emerging fluorescent molecular tracers to guide intra-operative surgical decision-making

P Debie, S Hernot - Frontiers in Pharmacology, 2019 - frontiersin.org
Fluorescence imaging is an emerging technology that can provide real-time information
about the operating field during cancer surgery. Non-specific fluorescent agents, used for …

Highly sensitive electrochemical detection of circulating EpCAM-positive tumor cells using a dual signal amplification strategy

AB Hashkavayi, BS Cha, SH Hwang, J Kim… - Sensors and Actuators B …, 2021 - Elsevier
Circulating tumor cells (CTCs) play an important role in diagnosing cancer and metastasis;
thus, appropriate sensors are required for analyzing CTCs in patient samples. Here, we …

Exploiting molecular probes to perform near‐infrared fluorescence‐guided surgery

Y Wu, F Zhang - View, 2020 - Wiley Online Library
Near‐infrared (NIR) fluorescence imaging can provide real‐time navigation for surgeons to
discriminate boundaries between lesions and healthy tissue, which serves as a promising …

Fluorescence molecular targeting of colon cancer to visualize the invisible

TM Lwin, MA Turner, S Amirfakhri, H Nishino… - Cells, 2022 - mdpi.com
Colorectal cancer (CRC) is a common cause of cancer and cancer-related death. Surgery is
the only curative modality. Fluorescence-enhanced visualization of CRC with targeted …

Fluorescence-guided tumor detection with a novel anti-EpCAM targeted antibody fragment: preclinical validation

LSF Boogerd, MC Boonstra, HAJM Prevoo… - Surgical oncology, 2019 - Elsevier
Tumor-specific fluorescent imaging agents are moving towards the clinic, supporting
surgeons with real-time intraoperative feedback about tumor locations. The epithelial cell …

X-ray and MR contrast bearing nanoparticles enhance the therapeutic response of image-guided radiation therapy for oral cancer

G Sharma, MH Razeghi Kondelaji… - … in Cancer Research …, 2023 - journals.sagepub.com
Introduction Radiation therapy for head and neck squamous cell carcinoma is constrained
by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for …

Side-by-side comparison of uPAR-targeting optical imaging antibodies and antibody fragments for fluorescence-guided surgery of solid tumors

VM Baart, L van Manen, SS Bhairosingh… - Molecular Imaging and …, 2021 - Springer
Purpose Radical resection is paramount for curative oncological surgery. Fluorescence-
guided surgery (FGS) aids in intraoperative identification of tumor-positive resection …