Latest developments in molecular tracers for fluorescence image-guided cancer surgery
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …
Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?
O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …
Next generation NIR fluorophores for tumor imaging and fluorescence-guided surgery: A review
Cancer is a group of diseases responsible for the major causes of mortality and morbidity
among people of all ages. Even though medical sciences have made enormous growth …
among people of all ages. Even though medical sciences have made enormous growth …
Emerging fluorescent molecular tracers to guide intra-operative surgical decision-making
P Debie, S Hernot - Frontiers in Pharmacology, 2019 - frontiersin.org
Fluorescence imaging is an emerging technology that can provide real-time information
about the operating field during cancer surgery. Non-specific fluorescent agents, used for …
about the operating field during cancer surgery. Non-specific fluorescent agents, used for …
Highly sensitive electrochemical detection of circulating EpCAM-positive tumor cells using a dual signal amplification strategy
AB Hashkavayi, BS Cha, SH Hwang, J Kim… - Sensors and Actuators B …, 2021 - Elsevier
Circulating tumor cells (CTCs) play an important role in diagnosing cancer and metastasis;
thus, appropriate sensors are required for analyzing CTCs in patient samples. Here, we …
thus, appropriate sensors are required for analyzing CTCs in patient samples. Here, we …
Exploiting molecular probes to perform near‐infrared fluorescence‐guided surgery
Near‐infrared (NIR) fluorescence imaging can provide real‐time navigation for surgeons to
discriminate boundaries between lesions and healthy tissue, which serves as a promising …
discriminate boundaries between lesions and healthy tissue, which serves as a promising …
Fluorescence molecular targeting of colon cancer to visualize the invisible
Colorectal cancer (CRC) is a common cause of cancer and cancer-related death. Surgery is
the only curative modality. Fluorescence-enhanced visualization of CRC with targeted …
the only curative modality. Fluorescence-enhanced visualization of CRC with targeted …
Fluorescence-guided tumor detection with a novel anti-EpCAM targeted antibody fragment: preclinical validation
LSF Boogerd, MC Boonstra, HAJM Prevoo… - Surgical oncology, 2019 - Elsevier
Tumor-specific fluorescent imaging agents are moving towards the clinic, supporting
surgeons with real-time intraoperative feedback about tumor locations. The epithelial cell …
surgeons with real-time intraoperative feedback about tumor locations. The epithelial cell …
X-ray and MR contrast bearing nanoparticles enhance the therapeutic response of image-guided radiation therapy for oral cancer
G Sharma, MH Razeghi Kondelaji… - … in Cancer Research …, 2023 - journals.sagepub.com
Introduction Radiation therapy for head and neck squamous cell carcinoma is constrained
by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for …
by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for …
Side-by-side comparison of uPAR-targeting optical imaging antibodies and antibody fragments for fluorescence-guided surgery of solid tumors
VM Baart, L van Manen, SS Bhairosingh… - Molecular Imaging and …, 2021 - Springer
Purpose Radical resection is paramount for curative oncological surgery. Fluorescence-
guided surgery (FGS) aids in intraoperative identification of tumor-positive resection …
guided surgery (FGS) aids in intraoperative identification of tumor-positive resection …