Anticancer drugs: recent strategies to improve stability profile, pharmacokinetic and pharmacodynamic properties

G Ioele, M Chieffallo, MA Occhiuzzi, M De Luca… - Molecules, 2022 - mdpi.com
In past decades, anticancer research has led to remarkable results despite many of the
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …

[HTML][HTML] Nanostructured lipid carriers and their potential applications for versatile drug delivery via oral administration

VN Thuy, TV Van, AH Dao, BJ Lee - OpenNano, 2022 - Elsevier
Enteral administration is the most convenient route despite the gastrointestinal physiological
barriers. Nanostructured lipid carriers (NLCs) have emerged as a promising strategy for …

Nanomedicine-based delivery strategies for breast cancer treatment and management

P Tagde, A Najda, K Nagpal, GT Kulkarni… - International journal of …, 2022 - mdpi.com
Breast cancer is one of the most common types of cancer among women globally. It is
caused by mutations in the estrogen/progesterone receptors and conventional treatment …

Propolis-loaded nanostructured lipid carriers halt breast cancer progression through miRNA-223 related pathways: an in-vitro/in-vivo experiment

SA Shaker, SM Alshufta, MA Gowayed… - Scientific Reports, 2023 - nature.com
The most frequent malignant tumor in women is breast cancer, and its incidence has been
rising every year. Propolis has been used for its antibacterial, antifungal, and anti …

Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications …

S Javed, B Mangla, Y Almoshari, MH Sultan… - Nanotechnology …, 2022 - degruyter.com
The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid
nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and …

Hepatoprotective effect of curcumin nano-lipid carrier against cypermethrin toxicity by countering the oxidative, inflammatory, and apoptotic changes in wistar rats

S Hussain, M Ashafaq, S Alshahrani, IAM Bokar… - Molecules, 2023 - mdpi.com
This study investigated the potential hepatoprotective activity of curcumin-incorporated nano-
lipid carrier (Cur-NLC) against cypermethrin (Cyp) toxicity in adult Wistar male rats. All …

Optimization of gefitinib-loaded nanostructured lipid carrier as a biomedical tool in the treatment of metastatic lung cancer

AY Sherif, GI Harisa, AA Shahba, FK Alanazi, W Qamar - Molecules, 2023 - mdpi.com
Gefitinib (GEF) is utilized in clinical settings for the treatment of metastatic lung cancer.
However, premature drug release from nanoparticles in vivo increases the exposure of …

Leveraging nanostructured lipid carriers to enhance targeted delivery and efficacy in breast cancer therapy: a comprehensive review

N Naseem, P Kushwaha, F Haider - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Cancer, characterized by uncontrolled cell growth and proliferation, continues to be a major
global health concern. Breast cancer, the most commonly diagnosed cancer among women …

Insights into lipid-based delivery nanosystems of protein-tyrosine kinase inhibitors for cancer therapy

J Jampilek, K Kralova - Pharmaceutics, 2022 - mdpi.com
According to the WHO, cancer caused almost 10 million deaths worldwide in 2020, ie,
almost one in six deaths. Among the most common are breast, lung, colon and rectal and …

[HTML][HTML] Heme oxygenase 1 inhibitor discovery and formulation into nanostructured lipid carriers as potent and selective treatment against triple negative metastatic …

NF Virzì, C Alvarez-Lorenzo, A Concheiro… - International Journal of …, 2025 - Elsevier
Abstract Heme oxygenase-1 (HO-1) has been identified as a potential new target in
anticancer therapy, being overexpressed in different tumors and crucial for cell proliferation …