An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Abstract Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …

Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …

Iron is a constituent of many metalloproteins involved in vital metabolic functions. While
adequate iron supply is critical for health, accumulation of excess iron promotes oxidative …

NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of
ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in …

Ferroptosis is a regulated cell death characterized by a lethal accumulation of lipid
peroxides due to an increase of intracellular iron and a decrease of antioxidant capacity …

Many patients with heart failure have an iron‐deficient state, which can limit erythropoiesis in
erythroid precursors and ATP production in cardiomyocytes. Yet, treatment with sodium …

Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …

Ferritinophagy is a type of autophagy mediated by nuclear receptor activator 4 (NCOA4),
which plays a role in inducing ferroptosis by regulating iron homeostasis and producing …