Molecular mechanisms of iron and heme metabolism
An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …
The role of NCOA4-mediated ferritinophagy in ferroptosis
N Santana-Codina, A Gikandi, JD Mancias - Ferroptosis: Mechanism and …, 2021 - Springer
Abstract Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …
To address this problem, several therapeutic approaches have been proposed, including …
NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron–sulfur cluster proteins
Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …
Basics and principles of cellular and systemic iron homeostasis
A Katsarou, K Pantopoulos - Molecular aspects of medicine, 2020 - Elsevier
Iron is a constituent of many metalloproteins involved in vital metabolic functions. While
adequate iron supply is critical for health, accumulation of excess iron promotes oxidative …
adequate iron supply is critical for health, accumulation of excess iron promotes oxidative …
NCOA4-mediated ferritinophagy: a potential link to neurodegeneration
M Quiles del Rey, JD Mancias - Frontiers in neuroscience, 2019 - frontiersin.org
NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of
ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in …
ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in …
[HTML][HTML] NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells
Ferroptosis is a regulated cell death characterized by a lethal accumulation of lipid
peroxides due to an increase of intracellular iron and a decrease of antioxidant capacity …
peroxides due to an increase of intracellular iron and a decrease of antioxidant capacity …
How can sodium–glucose cotransporter 2 inhibitors stimulate erythrocytosis in patients who are iron‐deficient? Implications for understanding iron homeostasis in …
M Packer - European journal of heart failure, 2022 - Wiley Online Library
Many patients with heart failure have an iron‐deficient state, which can limit erythropoiesis in
erythroid precursors and ATP production in cardiomyocytes. Yet, treatment with sodium …
erythroid precursors and ATP production in cardiomyocytes. Yet, treatment with sodium …
Crosstalk between autophagy and ferroptosis and its putative role in ischemic stroke
J Liu, ZN Guo, XL Yan, S Huang, JX Ren… - Frontiers in Cellular …, 2020 - frontiersin.org
Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …
The critical role of ferritinophagy in human disease
MZ Liu, N Kong, GY Zhang, Q Xu, Y Xu, P Ke… - Frontiers in …, 2022 - frontiersin.org
Ferritinophagy is a type of autophagy mediated by nuclear receptor activator 4 (NCOA4),
which plays a role in inducing ferroptosis by regulating iron homeostasis and producing …
which plays a role in inducing ferroptosis by regulating iron homeostasis and producing …