The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

Trinucleotide expansion underlies several human diseases. Expansion occurs during
multiple stages of human development in different cell types, and is sensitive to the gender …

DNA damage is a form of cell stress and injury that has been implicated in the pathogenesis
of many neurologic disorders, including amyotrophic lateral sclerosis, Alzheimer disease …

Aim: Oxidative stress has long been considered as a major contributing factor in the
pathogenesis of Parkinson's disease. However, molecular sources for reactive oxygen …

Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …

At fifteen different genomic locations, the expansion of a CAG/CTG repeat causes a
neurodegenerative or neuromuscular disease, the most common being Huntington's …

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for
our societies with their aging populations. Accumulation of DNA damage has been …

Embryonic stem (ES) cells are rapidly proliferating, self-renewing cells that have the capacity
to differentiate into all three germ layers to form the embryo proper. Since these cells are …